Archives

• 1. Safety Uses of Phytomedicines in Pregnancy and Pediatrics: An Overview By-  *Sachan Anupam K, Pujari Neelkanth M  
  ( Posted On : 20-11-2015 )
• 2. Indian consumer’s buying behaviour and perception to herbal drugs: a report By-  Pujari Neelkanth M*, Sachan Anupam K, Gupta Deepika  
  ( Posted On : 20-11-2015 )
• 3. Fast dissolving tablets of poorly soluble drugs: preparation, characterization and evaluation: an overview By-  Tiwari Reshu, Singh Satya P, Kushwaha Poonam, Usmani Shazia  
  ( Posted On : 20-11-2015 )
• 4. Tea Tree Oil - Its Uses And Applications By-  Singh Widhilika, Singh Satya P, Akhter Juber, Kamal Mehnaz  
  ( Posted On : 20-11-2015 )

ABSTRACT: Intranasal route has potential to target brain and possesses several advantages over parenteral and oral routes in treating CNS disorders such as stroke, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, hormone replacement, epilepsy and psychiatric disorders. Many drugs have been developed but they failed in showing the concentration required for action. Therefore various strategies have been proposed to improve the delivery of drug to the tissue. Research has established that the nasal route is a safe, non-invasive, essentially painless and particularly suited for children and acceptable alternative to the parenteral administration of drugs. Nose-to-brain drug delivery of drugs is advantageous as it requires low dose of drug, avoids first pass effect and also it is fast in action and suitable for the drugs that degrades in gastrointestinal tract and improve the patient compliance to use an alternative therapy to conventional dosage form. Nose to brain drug delivery the drug directly enters into the brain through nasal route  and has been potentially explored as an alternative route for administration of vaccines and bio molecules such as proteins, peptides and non peptide drugs. The effect is often reached within 5 min for smaller drug molecules. This review intends to detail the recent advances in the field of brain-targeting, rational drug design, approach, factors affecting nasal absorption, devices and formulations. Illustrate the complexity of the problems those have to be overcome for successful brain targeting.

 

- Muhammad Hamza Khan*, Satya Prakash Singh, Vaseem A Ansari, Muhammad Arif, Juber Akhtar *