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ABSTRACT: Schiff bases of Fluroquinolones with 1,2,4-triazol were prepared by the reaction of
intermediate (4-amino-3-(4-pyridyl)-5-mercapto-1,2,4-triazol) in dimethyl formamide with the various
fluroquinolones in acidic medium. The chemical structures of prepared compounds were confirmed by 1H
NMR, 13C NMR, IR, Mass and elemental analysis. Antimicrobial activity studies were performed, in order
to provide insights into the mechanism of action of potential antimicrobial drugs for resistant
microorganisms. Antimicrobial activity of compounds was investigated in vitro under aseptic conditions,
using the disk diffusion method, against various gram positive and gram negative pathogenic
microorganisms such as Pseudomonas aeruginosa (P.A.), Staphylococcus aureus (S. aureus), Helicobacter
pylori (H. pylori), Escherichia coli (E. coli), Methicillin-resistant Staphylococcus aureus (MRSA) and some
fungal strains such as, Aspergillus fumigatus, Pneumocystis carinii and Aspergillus niger. A series of these
compounds were prepared and have been shown to inhibit pathogenic growth, judging from the area of the
zone of inhibition.
Keywords: Antimicrobial, Schiff base, Triazoles, Zone of Inhibition, Fluoroquinolone

 

- Sirbaiya Anup K.*, Siddiqui Hifazat H., Shakya Ashok K. *